It is 337 miles taking this route:
It is 324.74 miles according to MapQuest.
64 miles
about 370 miles
about 350 miles
223 miles
Rochester NY is 726 miles from Charlotte North Carolina.
Richmond, VA
about 55 miles taking NY-104A SOUTH to NY-104 WEST, and then NY-104 WEST to Rochester.
1149.57 miles
about 160 miles
338 miles
Rochester, NY from Orangeburg, NY is about 302 miles.