About 265 miles via I-26 and I-95.
320 miles taking this route:Take U.S. 278 WEST, from Hilton Head Island, to I-95 NORTH to FLORENCE.Take I-95 NORTH to I-40 WEST to RALEIGH at EXIT 421 in NORTH CAROLINA.Take I-40 WEST to Raleigh.
Exit the airport, stay in the right-hand lane, and then follow signs to I-95 NORTH to HILTON HEAD IS.Take I-95 NORTH to U.S. 278 to BEAUFORT and HILTON HEAD IS. at EXIT 8 in SOUTH CAROLINA. Turn right off the exit ramp onto U.S. 278 EAST to HILTON HEAD IS.Take U.S. 278 EAST to Hilton Head Island
Take I-95 SOUTH to US-278 to JASPER and HILTON HEAD ISLAND at EXIT 8 in SOUTH CAROLINA. On this route, bypass Richmond via I-295 (EXIT 84A.)Turn left off the exit ramp onto US-278 EAST to HILTON HEAD ISLAND. Take US-278 EAST to Hilton Head Island.
About 40 miles to Savannah/Hilton Head International Airport using US-278 and I-95.
108 miles taking this route:Take U.S. 17 SOUTH from Charleston to I-95 SOUTH to SAVANNAH.Take I-95 SOUTH to U.S. 278 to HILTON HEAD IS. at EXIT 8. TURN LEFT off the exit ramp onto U.S. 278 EAST to HILTON HEAD IS.Take U.S. 278 EAST to Hilton Head Island.
interstate 95
From Stateboro, GA to Hilton Head, SC on the highways it is approximately 95 Miles and about an hour and 50 minute drive. If you want to avoid the highways it will be about 95 and a half miles and around a 2 hour 10 minute drive. Of course bad traffic is going to make those estimated times much longer.
321 miles taking this route:Take I-40 EAST from Raleigh to I-95 SOUTH to FAYETTEVILLE off EXIT 328 A.Take I-95 SOUTH to U.S. 278 to HILTON HEAD ISLAND off EXIT 8; turn left off the exit ramp onto U.S. 278 EAST to HILTON HEAD ISLAND.Take U.S. 278 EAST to Hilton Head Island.
330 miles taking this route:Take I-85 SOUTH (towards CHARLOTTE), from High Point, to I-77 SOUTH to COLUMBIA off EXIT 38 in Charlotte.Take I-77 SOUTH to I-26 EAST (to I-95) at END I-77 in Columbia, SC.Take I-26 EAST to I-95 SOUTH to SAVANNAH off EXIT 169A.Take I-95 SOUTH to U.S. 278 EAST to HILTON HEAD ISLAND off EXIT 8.Take U.S. 278 EAST to Hilton Head Island.
Charleston is approximately 60 miles from Interstate 95. It is easily accessible via various routes that connect the city to the interstate.
It is about 2.5 to 4 hours, depending on which way you go.