The driving distance between Knoxville, TN and Elizabethton, TN is approximately 115 miles. The driving time would be approximately 2 hours if you were to travel non-stop in good driving conditions. (The driving time does not take into consideration conditions which may extend trip time such as weather, road work and rush hour traffic in urban areas.)
338 miles taking this route: Take U.S. 321 NORTH from Elizabethton to I-26 WEST to KINGSPORT in Johnson City. Take I-26 WEST to I-81 SOUTH to KNOXVILLE at EXIT 8A. Take I-81 SOUTH to I-40 WEST to KNOXVILLE at EXIT 1B. Take I-40 WEST to I-24 WEST to CLARKSVILLE at EXIT 211 in DOWNTOWN NASHVILLE. To bypass DOWNTOWN KNOXVILLE, take I-640 WEST (EXIT 393 off I-40). Take I-24 WEST to Clarksville.