The condition is passed on genetically in families. It occurs when a person inherits two recessive genes for the disease, one from each parent
ataxia, rash, mental and psychiatric abnormalities
Eating a healthy, high protein diet
John Hartnup Jr. was born in 1841.
John Hartnup Jr. died in 1892.
a laboratory test of the urine which will contain an abnormally high amount of amino acids (aminoaciduria).
Mental retardation, cerebral ataxia (muscle weakness), and delirium (a confused, agitated, delusional state)
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There are several types of aminoaciduria, including cystinuria, Hartnup disease, and Lowe syndrome. Cystinuria involves the excessive excretion of cystine in the urine, while Hartnup disease is characterized by the impaired absorption of amino acids. Lowe syndrome is a rare genetic disorder that affects various systems in the body, including the kidneys.
Niacin deficiency can be treated effectively with replacement of niacin in the diet. In the case of Hartnup disease, large quantities of niacin may be required for effective reversal of symptoms.
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Various diseases that cause prolonged diarrhea, with cirrhosis of the liver, alcoholism, long-term use of the antituberculosis drug isoniazid, those with malignant cancer or Hartnup disease.
40-200 mg of nicotinamide (a form of niacin) per day to prevent pellagra-like symptoms. Some patients may require dietary supplements of tryptophan.