It is an X-linked recessive disorder.
ALD (adrenoleukodystrophy) affects an estimated 1 in 18,000 to 1 in 50,000 people, varying based on geographic location and population. It is an inherited disorder that primarily affects males.
1992
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It was discovered by Haperfield and Spieler. ;)
deletion
That is the correct spelling of "adrenoleukodystrophy" (also called Siemerling-Creutzfeldt Disease and adrenomyeloneuropathy) a disorder affecting myelin sheaths in the nervous system.
10 billion percent!!
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The United Leukodystrophy Foundation (see related links) mentions an x-linked adrenoleukodystrophy, as well as other adrenoleukodystrophies that have multiple possible genetic causes.
Lorenzo inherited adrenoleukodystrophy (ALD) from his mother through an X-linked recessive inheritance pattern. This means that the gene mutation responsible for ALD is located on the X chromosome. Since females have two X chromosomes, a mother carrying one mutated copy can pass it to her son, who has only one X chromosome inherited from her. As a result, if that X chromosome carries the mutation, her son, like Lorenzo, can develop ALD.
Adrenoleukodystrophy (ALD) is primarily caused by a mutation in the ABCD1 gene, which encodes a protein involved in the transport of very long-chain fatty acids (VLCFAs) into peroxisomes. This mutation typically results in a loss of function of the ABCD1 protein, leading to the accumulation of VLCFAs in the body. The genetic mutation is inherited in an X-linked recessive manner, meaning it predominantly affects males, while female carriers may exhibit milder symptoms.
it is x linked an dpass down by the mother