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CS is inherited in an autosomal recessive pattern. In order for a child to be affected by CS, he or she must inherit a mutation (-) in the same CS gene from both parents. The parents and other "carriers" of a single CS gene mutation remain healthy. Once a couple are known to carriers, they have a 1 in 4 (25%) chance of having another child with CS.

http://www.cockaynesyndrome.net/main/AboutCS.aspx

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How is Treacher Collins Syndrome passed from parent to offspring?

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