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Look up ECT. Basically it causes a grand mal seizure. Epileptic seizures in depressed patients had been observed to bring them out of depressions. So doctors developed a method of inducing one when needed. It still is the only treatment known that works reliably in medication resistant depression. In the modern form anesthetics and paralytics are given before treatment so the patient won't hurt himself.

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Q: How is electrotherapy applied to the brain for depression?
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