The third class of antiretroviral drugs developed against HIV were the protease inhibitors. These work far back in the life cycle of HIV, after host cell integration but before budding. These drugs affect the enzyme protease, which is used to cut up the HIV protein to be packaged into virions.
When the cell produces HIV proteins, the raw material is in a long connected string. The enzyme protease acts as a "scissor" to cut up the string into the protein for each virion. Protease inhibitors prevent protease from doing this. They resemble pieces of the protein string that protease usually cuts. This disrupts the cutting process, which prevents the chain from being cut into small pieces, which prevents HIV from making copies of itself.
Protease inhibitor
The generic name for the brand name drug Fortase (protease inihibitor for HIV - AIDS) is saquinavir.
People contract HIV first. In time, they will develop AIDS-related diseases such as Kaposi's sarcoma or PCP (pneumocistis carinii pneumonia). Once they have AIDS-related diseases, they are typically diagnosed as having AIDS.
AIDS Related Complex
Protease inhibitors (PIs) are a class of medications used to treat or prevent infection by viruses, including HIV and Hepatitis C. PIs prevent viral replication by inhibiting the activity of HIV-1 protease, an enzyme used by the viruses to cleave nascent proteins for final assembly of new virons.
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AIDS was identified as a disease in 1982. For the history of AIDS, visit the Related Link.
Protease is an enzyme. It is essentially a protein. Protease is not a compound and therefore its formula cannot be given out. Protease are a class of enzymes involved in digesting proteins. The basic mode of action can be described as: Protein + Protease -----> Digested protein + protease Since enzymes do not react in a biochemical reaction (they are merely catalysis), protease appears on both sides of the reaction shown above
In 2009 there were 1000 AIDS related deaths in Canada.
Protease breaks down Protein into amino acids
AIDS-related KS tumors generally appear on the upper body, including the head, neck, and back
All 50 states had AIDS-related deaths in 2003.