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Entropy is a measure of randomness. A folded protein is less random than an unfolded protein so entropy is reduced, which is not favorable. However, the folding of a protein also increases the net entropy of the solution (due to intramolecular interactions and the hydrophobic effect). However, if the protein is being denatured with heat, urea, or something these effects are countered so the protein unfolds.

Source: Biochem exam key

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Q: How is protein folding related to entropy?
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Related questions

Is protein folding endergonic or exergonic?

it is endergonic because it reduces entropy


Is hemoglobin a protein that exhibits the quaternary structure of protein folding?

The tertiary structure is the folding


What are the different levels of protein folding?

Tertiary - the protein's natural three- dimensional conformation - and Quaternary - how separately related tertiary forms coalesce.


What is the process in which protein are built?

Translation and transcription. Then they go into protein folding.


Is entropy closely related to the 1st law of thermodynamics?

It is related to the 2nd law of thermodynamics


What organelles is responsible for folding protein in cell?

Rough endoplasmic reticulum.Rough endoplasmic reticulumB.Rough endoplasmic reticulum


What is secondary genetic code?

The secondary genetic code is the folding of protein.


Why can't entropy be destroyed?

The reason that entropy increases is related to statistics. It is possible in theory that a process occurs in such a way that entropy decreases, but this is so unlikely that it will never happen in practice.


Which type of protein shields a newly forming protein from cytoplasmic influences while it is folding into its functional form?

Chaperonins


What special protein help a protein fold correctly?

A chaperone protein is used in the cell to ensure proper protein folding, among other cellular functions.


What structure of a protein is the coiling or folding of a polypeptide chain?

Secondary structure. The coiling is the formation of the alpha helix. The folding is the formation of the beta sheets.


Which law is entropy closely related to?

Entropy is closely related to the second law of thermodynamics, which states that the entropy of a closed system will always remain the same or increase over time, but never decrease. This law describes the tendency of systems to move towards a state of maximum disorder or randomness.