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It depends on the specific cartridge. 12.7mm is equivalent to .50 calibre. A .50 AE (12.7x33) cartridge (as used in the Desert Eagle .50AE) will leave a very large crush cavity (damage caused by the projectile itself), but won't generate significant hydrostatic pressure (caused by air displacement around the moving projectile). A 12.7mm cartridge as used in the 12.7x99 (.50 BMG) or 12.7x108 cartridge, on the other, could take off a limb.

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