The driving distance between Buffalo, NY and Toledo, OH is approximately 310 miles. The driving time would be approximately 5 hours if you were to travel non-stop in good driving conditions. (The driving time does not take into consideration conditions which may extend trip time such as weather, road work, border crossings and rush hour traffic in urban areas.)
I takes about 1 hour and 54 minutes to drive from Buffalo,NY to Toronto,Ontario,Canada.
1890 kilometers (1174 miles).
Drive: about 2 hours
Assuming you meant Buffalo, NY to Manchester, NY. They are about 90 miles apart on the I-90E - 1.5 hours.
The distance between Buffalo, NY to Hilton Head, SC is about 912 miles which is about 15 hours and 8 minutes drive.
24 hours
The trip from Oakville, Ontario to Buffalo, NY takes about 2 hours; with a distance of 76.38 miles according to MapQuest.
395.7 miles, or about 6 hours and 11 minutes.
15 hours 38 minutes
1 hour and 55 minutes.
350 miles between Buffalo,NY and Schenectady, NY. Factoring a rest stop near Syracuse, the time is 5 hours.
about 420 miles to drive