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I can't answer how long it stays in your system, by when I went to consult with an ob-gyn about migraine medications and trying to get pregnant, he told me I could take imitrex from the first day of your period until I ovulated. So from that, I would guess it doesn't stay in your system too long, or he would have told me not to take it while trying to get pregnant. I would caution that sometimes when you get pregnant, you might have light spotting upon implantation of the egg into your uterine wall, so wait until you know for sure that your bleeding is actually your period.

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Q: How long does imitrex stay in your system How long after can we safely get pregnant?
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