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A really long time. Most turkey cooking times are based on 350 or 375 degrees so 225 would take much longer. 21 pounds is a lot of turkey, and it would be important if you stuffed your turkey or not.
The answer is basically 8 hours unstuffed. It would be best to use a meat thermometer to ensure that the breast and the thigh reached at least 165 degrees. If you don't have a meat thermometer, eight hours should be sufficient for you to go out and buy one.
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