About 5.5 to 6.5 hrs.
The answer to your question depends on how fast you drive and how many stops you have.
It is about 380 miles across Wyoming or about a seven hour drive.
Nebraska and South Dakota share a common border, so travel time would be as long as it takes someone to step across the state line.
About 45 minutes.
mapquest it
About 6 or 7 hours
two hours
100 miles
On average, about 12 and a half hours, depending on where in Nebraska you are going to.
12 hours
3 hours
About 10,000 miles