The trip from Alexandria to Cincinnati should take no longer than 9 hours. I used to drive from Louisville, Ky (1.5 hrs southwest of Cinci) to DC within 10 hours.
To drive along major roads from San Francisco, California, to Montreal, Canida, would take approximately 46 hours, at a total distance of about 3000 miles.
Freeport, Maine is a 6 hour drive from Montreal, Canada. There is about 256 miles between the two locations. A flight would take about an hour to complete.