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The driving distance between Amarillo, TX and San Antonio, TX is approximately 510 miles. The driving time would be approximately 8 hours 45 minutes if you were to travel non-stop in good driving conditions. (The driving time does not take into consideration conditions which may extend trip time such as weather, road work, border crossings and rush hour traffic in urban areas.)

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Q: How long does it take to drive from Amarillo to San Antonio?
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