7 hours and 12 minutes
It takes about 4 hours to drive the 246 miles from Madrid to Bilbao.
Calabria to Seville is 27 hours. Genoa to Girona is 8 and 1/2 hours. The number you're looking for is probably somewhere between the two.
It should take about 6.5 hours to drive the 422 miles from BilBao to Santiago de Compostela.
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