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Google Maps estimates the driving time as 5 hours and 20 minutes.

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Q: How long does it take to drive from Destin FL to Jacksonville FL?
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Destin to Jacksonville?

The distance between Destin and Jacksonville is around 350 miles, which would take roughly 6-7 hours to drive without traffic. The most common route is to take Interstate 10 East, which is a straightforward journey across northern Florida. Additionally, there are various stops along the way, such as Tallahassee and Lake City, if you need a break during the trip.