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The driving distance between Kansas City, MO and Jacksonville, FL is approximately 1125 miles. The driving time would be approximately 19 hours if you were to travel non-stop in good driving conditions. (The driving time does not take into consideration conditions which may extend trip time such as weather, road work, border crossings and rush hour traffic in urban areas.)

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Q: How long does it take to drive from Kansas City Missouri to Jacksonville Florida?
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