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The driving distance between Knoxville, TN and Pittsburgh, PA is approximately 495 miles. The driving time would be approximately 8 hours if you were to travel non-stop in good driving conditions. (The driving time does not take into consideration conditions which may extend trip time such as weather, road work, border crossings and rush hour traffic in urban areas.)

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Q: How long does it take to drive from Pittsburgh to Knoxville Tennessee?
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