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The driving distance between Poughkeepsie, NY and Columbia, MO is 1117 miles. The driving time would be approximately 17 hours, 30 minutes if you were to drive non-stop in good conditions. (The driving time does not take into consideration conditions such as weather, road work and rush hour traffic in urban areas.)

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Q: How long does it take to drive from Poughkeepsie NY to Columbia Missouri?
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