About 16 hours
At present no... The only carrier who currently fly the A380 to Los Angeles (LAX) is Qantas who opperate flight between LA and Sydney and LA and Melbourne. Qantas and Singapore Airlines both fly between Singapore and both Melbourne and Sydney so you could fly the A380 all the way to LA just not without a stopover also you have to take Qantas for at least one sector. See the related link below for complete listing of all routes and schedules flown by the A380. Includes schedules for Qantas, Singapore Airlines, Emirates and Air France (from Nov09).
You wouldn't be able to get a direct flight to Iowa from Melbourne so I would suggest travelling to LA (14 hour 20 minute approx flight) then catching a connecting flight to Iowa and it depends on where in Iowa you are going and if you can get a direct flight as to how long it would take. Hope this helped.
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