24 to 36 hours tops. Fentanyl is the fastest acting opioid on the market due to it's mode of action (mouth). It's fast in and fast out.
That is not a fully explained response. Oral Fentanyl, such as Actiq and Fentora only have a half-life of 4 to 6 hours. The patches can take up to approximately 24 to 30 hours once you remove them. Fentanyl metabolizes very quickly.
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