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5 and 1/2 to 6 hours
Whether you should drive or take a boat from Ft. Myers to Key West depends on how much time you have, what the weather along the route will be, the relative costs (boat is likely to be more costly), and whether you are more board by a long drive or an extended boat ride.
The Keys are 120 miles long. Fort Myers to Key West is 302 miles.
28hrs.
5 seconds
14 weeks
It is 160.34 miles according to MapQuest.
300 miles.
Ft. Lauderdale is farther from Key West then Miami. Therefore it is easier to drive from Miami to Key West.
4 1/2 hours
Map quest it.
12-13 hours