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The driving distance between Knoxville, TN and Philadelphia, PA is approximately 625 miles. The driving time would be approximately 10 hours 30 minutes if you were to travel non-stop in good driving conditions. (The driving time does not take into consideration conditions which may extend trip time such as weather, road work, border crossings and rush hour traffic in urban areas.)

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13y ago
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Q: How long is the drive from Philadelphia to Knoxville?
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