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The driving distance between Knoxville, TN and Orlando, FL is approximately 650 miles. The driving time would be approximately 10 hours 45 minutes if you were to travel non-stop in good driving conditions. (The driving time does not take into consideration conditions which may extend trip time such as weather, road work, border crossings and rush hour traffic in urban areas.)

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Q: How long is the drive time from Knoxville to Orlando?
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