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Opiates take about 72 hours (3 days) to leave your system.

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Q: How long will a small amount of opiate stay in your system?
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Can methadone clean out your system?

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Does methadone have opiate in them?

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Can the amount of methadone in a person's system be detected by urine?

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How long do Lortabs stay in system?

The prescription drug that is called Lortab is an opiate drug that can stay in your system anywhere from three days to two weeks. This largely depends on weight, dosage, and how often it is taken.