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How long melatonin remains in your bloodstream depends on a number of factors, including the size of the dose and the efficiency of your liver. On average,
doses smaller than 10 mg. are gone from the bloodstream within 12 hours, but if a person's liver allows melatonin to enter the bloodstream intact, it can last more than 12 hours. Variability in blood levels is one of the great difficulties for researchers who study melatonin.
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