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How many cases are there of people getting methemoglobinemia after using benezocaine?
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What Negative effects on radio?
It's an excellent media for getting your message out to many people. Extremely useful in cases of national emergencies.
How do you find the prbability of getting something?
There a formula: Probability = No. of Cases in favour / Total no. of cases
Methemoglobinemia?
DefinitionMethemoglobinemia is a blood disorder in which an abnormal amount of hemoglobin builds up in the blood. Hemoglobin is the oxygen-carrying molecule found in red blood cells. In some cases of methemoglobinemia, the hemoglobin is unable to carry oxygen effectively to body tissues.Alternative NamesHemoglobin M disease; Erythrocyte reductase deficiency; Generalized reductase deficiencyCauses, incidence, and risk factorsMethemoglobinemia may be passed down through families (inherited). Or, it may result from exposure to certain drugs, chemicals, or foods (acquired).There are two forms of inherited methemoglobinemia. The first form is passed on by both parents. The parents usually do not have the condition themselves, but they carry the gene that causes the condition. It occurs when there is a problem with an enzyme called cytochrome b5 reductase.There are two types of this form of methemoglobinemia:Type 1 (also called erythrocyte reductase deficiency) occurs when red blood cells lack the enzyme.Type 2 (also called generalized reductase deficiency) occurs when the enzyme doesn't work anywhere in the body.The second form of inherited methemoglobinemia, called hemoglobin M disease, is caused by defects in the hemoglobin molecule itself. Only one parent needs to pass on the abnormal gene in order for the child to inherit the disease.Acquired methemoglobinemia is more common than the inherited forms. It occurs after exposure to certain chemicals and drugs, including:Anesthetics such as benzocaine and XylocaineBenzeneCertain antibiotics (including dapsone and chloroquine)Nitrites (used as additives to prevent meat from spoiling)The condition may also occur in infants who are very ill or who are fed too many vegetables containing nitrates (such as beets).SymptomsSymptoms of type 1 methemoglobinemia (erythrocyte reductase deficiency) include:Bluish coloring of the skinSymptoms of type 2 methemoglobinemia (generalized reductase deficiency) include:Developmental delayFailure to thriveMental retardationSeizuresSymptoms of hemoglobin M disease include:Bluish coloring of the skinSymptoms of acquired methemoglobinemia include:Bluish coloring of the skinHeadacheFatigueShortness of breathLack of energySigns and testsMethemoglobinemia can be diagnosed with a blood test.A baby with this condition will have bluish skin color (cyanosis) at birth or shortly thereafter. Arterial blood gases and pulse oximetry results will be normal, making the condition challenging to diagnose.TreatmentA medicine called methylene blue is used to treat persons with severe methemoglobinemia. Note: Methylene blue may be dangerous in patients who have or may be at risk for a blood disease called G6PD deficiency, and should not be used. If you or your child has G6PD deficiency, always tell your health care provider before receiving treatment.Ascorbic acidmay also be used to reduce the level of methemoglobin.Alternative treatments include hyperbaric oxygen therapyand exchange transfusions.In most cases of mild acquired methemoglobinemia, no treatment is required. However, you should avoid the medicine or chemical that caused the problem. Severe cases may need treatment, such as a blood transfusion.Expectations (prognosis)People with Type 1 methemoglobinemia and hemoglobin M disease usually do well. Type 2 methemoglobinemia is much more serious, and usually causes death within the first few years of life.People with acquired methemoglobinemia usually do very well once the drug, food, or chemical that caused the problem is identified and avoided.ComplicationsShockSeizuresDeathCalling your health care providerCall your health care provider if you have a family history of methemoglobinemia and you develop symptoms of this disorder.Call your health care provider or emergency services immediately if you have severe shortness of breath.PreventionGenetic counseling is recommended for couples with a family history of methemoglobinemia who are considering having children.ReferencesDeBaun MR, Vichinsky E. Hemoglobinopathies. In: Kliegman RM, Behrman RE, Jenson HB, Stanton BF, eds. Nelson Textbook of Pediatrics. 18th Ed. Philadelphia, PA: Saunders Elsevier; 2007: chap 462.Gregg XT, Prchal JT. Red blood cell enzymopathies. In: Hoffman R, Benz EJ Jr., Shattil SS, eds. Hematology: Basic Principles and Practice. 5th ed. Philadelphia, PA: Elsevier Churchill Livingston; 2008: chap 45.
How should you go about getting the correct cases when you assemble bills and products that are sensative?
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Methemoglobinemia - acquired?
DefinitionMethemoglobinemia is a blood disorder in which the body cannot reuse hemoglobinafter it is damaged. Hemoglobin is the oxygen-carrying molecule found in red blood cells. In some cases of methemoglobinemia, the hemoglobin is unable to effectively carry oxygen to body tissues.Acquired methemoglobinemia results from exposure to certain drugs, chemicals, or foods.The condition may also be passed down through families (inherited). See: MethemoglobinemiaReferencesSteinberg MH. Sickle cell disease and associated hemoglobinopathies. In: Goldman L, Ausiello D, eds. Cecil Medicine. 23rd ed. Philadelphia, Pa: Saunders Elsevier; 2007:chap 167.
What are the chances of getting dreams?
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