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614 miles taking this route:
- Take I-64 EAST, from Louisville, to I-75 SOUTH to KNOXVILLE in Lexington.
- Continue on I-75 SOUTH to I-40 EAST to ASHEVILLE, via I-640 EAST to bypass KNOXVILLE.
- Take I-40 EAST to I-26 EAST to SPARTANBURG at EXIT 46A in Asheville.
- Take I-26 EAST to Charleston.
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