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Depends where in Mississippi you are leaving from. Biloxi to Ft Lauderdale is 20-21 hours. Anywhere north of there will take a bit longer. Check on the Greyhound web site to find the nearest bus station from where you are, they provide an estimated travel time. I have traveled with Greyhound more than once and they are pretty good at keeping to the schedule. Of course they are not able to control the amount of traffic, accidents, or other variables but my experience has been positive.

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Q: How many hours does it take for a Greyhound bus to go from Mississippi to Fort Pierce FL?
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