About 20 hours.
It takes about 4 hours to drive the 246 miles from Madrid to Bilbao.
Around four or five hours.
6 hours
The drive is 249 miles, normally about 4 1/2 hours.
There are 533 km. (333 mi.) from Madrid to Sevilla. It takes about 5 hours and 35 minutes to drive. You can do it in about 2 - 2.5 hours on the AVE train I think.
There are 323 miles fro Aveiro Portugal to Madrid Spain. It should take five and one half to six hours to drive.
Yes, it is possible to drive from Madrid, Spain to Rome, Italy. The driving distance is 1,218 miles and the trip takes from 18 hours 4 minutes to 18 hours 50 minutes.
868 miles, 13 and 1/2 hours
The drive from Madrid to Barcelona is 623 km - about 6 hours 6 mins. By bus, about 8 hours.
The shortest drive is about 4 and a half hours, while the longest is about 5 and a half hours.
WikiAnswerer #1: It takes six hours to drive from Madrid, Spain to New York City, New York. WikiAnswerer #2: Six hours? How is that possible? It takes seven hours to fly there! WikiAnswerer #1: A six-hour drive gets you from Madrid to the Atlantic Ocean, at Lisbon, Portugal. After that it's float time, which is anyone's guess!
About 17 hours and 15 minutes (1,069 miles)