Approximately 23-25 hours of DRIVING time including a reasonable allowance for gasoline and comfort breaks depending on the exact route and and traffic conditions through several metropolitan areas.
Realistically, about 2½ days of driving for one driver to complete safely.
Two drivers in tandem with a proper sleeping area in the vehicle can complete this drive in 24 hours (including short fuel and comfort stops).
The shortest route is counter intuitive:
I74 to Indianapolis
I70 to St. Louis
I44 to Oklahoma City
I40 to Albuquerke
(This route has toll roads)
There are several alternate routes to avoid tolls and some heavy traffic areas but would be longer in distance, but not much difference in time. Taking I71 to Lousville then I64 to St. Louis would be marginally longer and would bypass Indianapolis and Terra Houte. It also has an approach to St. Louis that is regularly less congested.
To avoid tolls one could remain on I70 through Missouri to Kansas City then take US50 to US 56 and follow US 56 all the way to Albuquerque. This adds only a few miles but it is a standard highway, not an interstate. Depending on conditions it could add a significant amount of time to the journey. But all things being equal it would only add about an hour to the trip.
The Southern Route might be an option during winter to avoid dangerous weather (ice/snow) but that could add several hours to the trip time. I71 to Louisville to I65 to Nashville to I40 all the way to Albuquerque. This is over 100 miles longer and goes though several MAJOR heavy traffic zones including Nashville, Memphis and Dallas.
25
Albuquerque, NM (ABQ) to Rome (ROM) Shortest Flight Duration * 13 hours 5 mins * Via Cincinnati Northern Kentucky Intl Apt, Cincinnati (CVG)
The shortest time is about 16 hours.
7 hours
20 hours and 6 minutes
MapQuest estimates the driving time as 3 hours and 7 minutes.
MapQuest estimates the driving time as 8 hours and 1 minute.
It is 9 hours and 25 minutes according to MapQuest.
It is 215 miles and 3.75 hours of driiviing time.
27 hours
There is one hour between the two cities.
It is 725.31 miles according to MapQuest.