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It is a 126 miles from Tampa to Fort Meyers.
MapQuest estimates the driving time as 12 hours and 48 minutes.
Fort Myers to Key Largo is 200.92 miles and would take 3 hours and 23 minutes to drive. [Source: Mapquest]
125 Miles
215 miles
42.77 miles
About 60 miles on I-75 N.
2 and a half hours.
135 miles taking this route:Take I-595 WEST, from Ft. Lauderdale, to I-75 NORTH to NAPLES.Take I-75 NORTH to Ft. Myers.
10 hours
5 hours
It's about 5 hours.