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Men with a history of childhood cryptorchidism are three to 14 times more likely to develop testicular cancer.

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Testicular cancer can have a hereditary link, though it’s not very common. Men with a close family history, especially a father or brother with testicular cancer, are at a higher risk. Certain genetic conditions, like undescended testicles or Klinefelter syndrome, may also contribute. While heredity increases risk, most cases occur in men without any family history. It’s important for all men to stay aware of changes and perform regular self-exams, regardless of their genetic background, to catch any issues early.


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Where does testicular cancer originate from?

The exact cause of testicular cancer is unknown. There is no link between vasectomy and testicular cancer. Factors that may increase a man's risk for testicular cancer include:Abnormal testicle developmentHistory of testicular cancerHistory of undescended testicle(s)Klinefelter syndromeOther possible causes include exposure to certain chemicals and HIV infection. A family history of testicular cancer may also increase risk.Testicular cancer is the most common form of cancer in men between the ages of 15 and 35. It can occur in older men, and rarely, in younger boys.White men are more likely than African-American and Asian-American men to develop this type of cancer.There are two main types of testicular cancer: seminomas and nonseminomas. These cancers grow from germ cells, the cells that make sperm.Seminoma: This is a slow-growing form of testicular cancer usually found in men in their 30s and 40s. The cancer is usually just in the testes, but it can spread to the lymph nodes. Seminomas are very sensitive to radiation therapy.Nonseminoma: This more common type of testicular cancer tends to grow more quickly than seminomas. Nonseminoma tumors are often made up of more than one type of cell, and are identified according to these different cell types:Choriocarcinoma (rare)Embryonal carcinomaTeratomaYolk sac tumorA stromal tumor is a rare type of testicular tumor. They are usually not cancerous. The two main types of stromal tumors are Leydig cell tumors and Sertoli cell tumors. Stromal tumors usually occur during childhood.


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What occurs as a result of undescended testes?

The most common problems associated with undescended testicles are testicular neoplasm, subfertility, testicular torsion and inguinal hernia. Also, it has been well documented that men with a history of undescended testicle have a higher-than-expected incidence of testicular germ cell cancers. While the likelihood of developing testicular cancer has probably been overestimated in the past, the incidence among men with an undescended testicle is approximately one in 1,000 to one in 2,500. Undescended testicles can be categorized on the basis of physical and operative findings: (1) true undescended testicles (including intra-abdominal, peeping at the internal ring and canalicular testes), which exist along the normal path of descent and have a normally inserted gubernaculum; (2) ectopic testicles, which have an abnormal gubernacular insertion; and (3) retractile testicles, which are not truly undescended. The most important category to distinguish on physical examination is the retractile testis, because no hormone or surgical therapy is required for this condition. Approximately 20 percent of infants who present with cryptorchidism have at least one nonpalpable testicle. Through surgical examination, about one half of nonpalpable testes are found to be intra-abdominal, while the rest represent absent (vanishing) or atrophic testes. The vanishing testicle is thought to be caused by intrauterine testicular torsion.


How is testicular cancer prevented?

It's almost totally random.....the biggest risk factor is undescended testicle from birth, which ups your risk about 15-fold. And it affects caucasions more than Hispanics and MUCH more than African Americans. Having said all that, it's rare and the odds of getting it are slim.