How many miles between Key largo and fort Myers fl?

200 miles taking this route:

  1. Take U.S. 1 NORTH from Key Largo to Florida's TURNPIKE (toll) NORTH to ORLANDO in Homestead/Florida City.
  2. Take the TURNPIKE (toll) NORTH to I-75 NORTH to NAPLES at EXIT 39.
  3. Take I-75 NORTH to Ft. Myers.