There is no way to be 100% sure of that, typically miles a car can take depend totally on the driver at hand. If it is driven well, I wouldn't see any reason why it wouldn't get over 220,000.
A Cadillac Escalade hybrid from 2011 uses 20 miles per gallon. The model from just a year earlier, 2010, uses 14-18 miles per gallon. So a 2011 Cadillac Escalade gets more miles out of the gas.
Up to 300,000 miles!
The EPA range estimate for the 2009 Cadillac Escalade-EXT is N in the city, A on the highway.
The EPA range estimate for the 2010 Cadillac Escalade-EXT is N in the city, A on the highway.
If it is maintained correctly 300K plus
The EPA range estimate for the 2009 Cadillac Escalade is 312.0 mi. in the city, 494.0 mi. on the highway.
The EPA range estimate for the 2011 Cadillac Escalade is 364.0 mi. in the city, 468.0 mi. on the highway.
The EPA range estimate for the 2012 Cadillac Escalade is 364.0 mi. in the city, 468.0 mi. on the highway.
The EPA range estimate for the 2002 Cadillac Escalade is 338 mi. in the city, 442 mi. on the highway.
The EPA range estimate for the 2008 Cadillac Escalade is 312.0 mi. in the city, 494.0 mi. on the highway.
The EPA range estimate for the 2006 Cadillac Escalade is 338.0 mi. in the city, 442.0 mi. on the highway.
The EPA range estimate for the 2007 Cadillac Escalade is 312.0 mi. in the city, 494.0 mi. on the highway.