How many miles is it from Indianapolis Indiana to Destin Florida?

Answer 1

It is around 730 miles.

The route:

1) Take I-65 SOUTH through Indiana, Kentucky and Tennessee, through Louisville and Bowling Green, KY, through Nashville, TN, and through Birmingham and Mobile, AL to AL-97 at EXIT 151.

2) Turn left off the exit ramp and take AL-97 SOUTH to US-331. Continue straight on US-331 SOUTH.

3) Take US-331 SOUTH through Alabama to US-98 in Florida.

4) Turn right onto US-98 and take US-98 WEST to Destin.