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468 miles taking this route:

  1. Take I-94 EAST from Milwaukee to I-65 SOUTH to INDIANAPOLIS at EXIT 11 in Chicagoland, Indiana. To bypass Chicago, take I-294 (Tri-State) TOLLWAY - SOUTH.
  2. Take I-65 SOUTH to I-74 EAST via I-865 EAST (EXIT 129 off I-65) and I-465 (EXIT 49 off I-465 to get onto I-74 EAST to CINCINNATI) to bypass INDIANAPOLIS.
  3. Take I-74 EAST to I-75 SOUTH via I-275 SOUTH to bypass CINCINNATI. (EXIT 5 off I-74 in OHIO to get onto I-275 SOUTH to Kentucky ; EXIT 84 off I-275 in northern KENTUCKY to get onto I-75 SOUTH to LEXINGTON.)
  4. Take I-75 SOUTH to Lexington.
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Q: How many miles is it from Milwaukee Wisconsin to lexington Kentucky?
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