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How may zolpidem act with other drugs?

Updated: 8/19/2019
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GaleEncyofMedicine

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13y ago

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it may add to the effects of alcohol and other drugs that slow down the central nervous system, such as antihistamines, cold medicine, allergy medicine, medicine for seizures, tranquilizers, some pain relievers, and muscle relaxants.

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Q: How may zolpidem act with other drugs?
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Can you take fluvoxamine and zolpidem together?

You can check all known interactions of drugs yourself with the website http://www.drugs.com/drug_interactions.php. Simply type in the drugs you wish to find and select the correct drug from the dropdown menu. All known interactions will then appear.---- Interactions searched:* fluvoxamine * zolpidem ---- 1 Interaction found:# zolpidem and fluvoxamine (Minor Drug-Drug) MINOR PROBLEM: Use of drugs that inhibit the isoenzyme CYP450 3A4 may decrease the metabolism and increase the plasma levels of zolpidem. This can result in increased clinical effectiveness and risk of toxicity associated with zolpidem. Monitoring for signs and symptoms of altered zolpidem effect is recommended. Patients should be advised to notify their physician if they experience nausea, vomiting, diarrhea, confusion, daytime sedation, dizziness, or unconsciousness. A reduction in zolpidem dosage may be necessary. ----


What drugs may interact with zolpidem?

Other central nervous system (CNS) depressants such as medicine for allergies, colds, hay fever, and asthma; sedatives; tranquilizers; prescription pain medicine; muscle relaxants; medicine for seizures; barbiturates; and anesthetics.


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== DRUG CLASS AND MECHANISM: Zolpidem belongs to a class of�drugs called sedatives or�hypnotics. Zolpidem is closely related to a family of�sedatives called benzodiazepines. These drugs cause sedation, muscle relaxation, act as anti-convulsants (anti-seizure), and reduce anxiety. Zolpidem has selectivity in that it has little of the muscle relaxant�and anti-seizure effects and more of the sedative effect. Therefore, it is used as a medication for sleep. Researcher's note: For example, Valium is diazepam. I think Ambien has been around for decades under other trade names, different in the U.S. and other countries. PRESCRIPTION: Yes GENERIC AVAILABLE: Yes PREPARATION: Tablets, 5 and 10 mg STORAGE: Zolpidem should be stored at room temperature in a tight container. PRESCRIBED FOR: Zolpidem is used as a sleeping pill to treat insomnia. It has been shown to put patients to sleep more rapidly�and keep them asleep longer. Sleeping pills generally are not prescribed for more than 10 days and are usually taken intermittently as needed to avoid problems with addiction or habituation, loss of effectiveness, and rebound phenomena. DOSING: Zolpidem should be taken without food at bedtime to induce a rapid onset of sleep. Zolpidem is eliminated�by the liver, and doses need to be decreased in patients with liver dysfunction (e.g., hepatitis). Lower doses should be used in the elderly because of their decreased ability to�eliminate zolpidem from the body. DRUG INTERACTIONS: Alcohol has an additive effect with zolpidem and the two should not be combined. Zolpidem should be used cautiously in patients with respiratory diseases because of its depressing effect on breathing. Zolpidem has few drug interactions with other medicines; however, caution should be used when combining it with other sedative drugs because of the additive effects. Zolpidem used at higher dosages can cause withdrawal symptoms (muscle cramps, sweats, shaking, and seizures) when the drug is abruptly discontinued. Zolpidem can cause abnormal behavior with confusion, paradoxical insomnia or "complex sleep-related behaviors which may include sleep-driving (driving with no memory of having done so).� If these side effects occur, zolpidem should be discontinued. SIDE EFFECTS: The most common side effects of Zolpidem are drowsiness, dizziness, and a "drugged" feeling, which probably reflect the action of the drug. Other side effects include confusion, insomnia, euphoria, ataxia (balance problems), and visual changes.


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