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There shouldn't be any tolls. If you take I75 straight down to I40, you can cut across I40 and where you go from there depends on where in SC you're going... you can take I26, I85, I77, or I95 into SC, plus several state and US highways.

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Q: How much does it cost in tolls to travel from Detroit to South Carolina if you are driving an 18 wheeler?
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