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Splenda is made from sucralose. Results from over 100 animal and clinical studies in the FDA approval process unanimously indicated a lack of risk associated with sucralose intake. However, some adverse effects were seen at doses that significantly exceeded the estimated daily intake (EDI), which is 1.1 mg/kg/day.

A Duke University study found evidence that doses of Splenda of between 100 and 1000 mg/kg, containing sucralose at 1.1 to 11 mg/kg reduced the amount of good bacteria in the intestines of rats by up to 50%, increased the pH level in the intestines, contributed to increases in body weight, and affected the levels of P-glycoprotein (P-gp). These effects have not been reported in humans. An expert panel, including scientists from Rutgers University, New York Medical College, Harvard School of Public Health, Columbia University, and Duke University reported in Regulatory Toxicology and Pharmacology that the Duke study was "not scientifically rigorous and is deficient in several critical areas that preclude reliable interpretation of the study results". Another report suggests sucralose was a possible trigger for some migraine patients. Another study, published in the Journal of Mutation Research, linked large doses of sucralose equivalent to 11,450 packets (136 g) per day in a person to DNA damage in mice.

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14y ago

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