It helps to know where you are traveling from.
Northeast.
You would travel the National Road.
It is over 24 Hours
lawerence
Maryland, Pennsylvania, Texas, Florida, and more
From Baltimore, Maryland to Titusville, Florida it is about 886 miles travel time by car is about 13 hours.
Annapolis, Maryland
Consider using the MARC commuter line.
About 6 to 8 hours at most
Virginia, Maryland, Pennsylvania.
PennsylvaniaVirginia (west Virginia)OhioIndiana
The states of Maryland and Pennsylvania are border states. Theoretically if you stood with one foot in Maryland and on foot in Pennsylvania it would take no time to get there. Re-ask your question with cities or towns if you would like.