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Depending on your definition of "out of your system", yes and no.

Oxycodone has a half life of 3 - 4.5 hours. The math is easier with 4 hours. With a 4 hour half-life, after 24 hours, you would have 1.5% of the drug left in your system. After 2 days, 0.02% will be left in your system. By the 4th day it's down to about a millionth of a percent. So, in other words, after 2 days, it's effectively gone.

Now, if you're asking with regards to drug testing, that's different (and I don't mean to imply that it is, but drug testing is a common subject here), the tests usually don't test for the presence of the drug itself, but for metabolites of the drug. That is, most drugs enter your system as one chemical and exit it as different chemicals. The body breaks it down into other things, and some of those other things will hang around much longer.

I don't know what the time frame is for oxycodone, but based on similar drugs, I suspect it's testable in urine for 1-5 days, testable in the blood probably 6-12 hours, and testable in the hair for about 90 days.

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Q: If I exercise five days a week will oxycodone be out of my system in four days?
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