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Within transplantation surgery, there is nothing to be "sure" about, even when working with allograft transplants. With xenograft transplants (which are exceptionally rarely performed), risks are much higher and there are additional risks which do not occur with allograft transplants. In either case, there is no way to be "sure" of a good outcome, due to the many known and unknown random variables which affect outcomes.

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Q: If a xenotransplant was done for a human how can you be sure that the organ put into the human will grow properly with the human?
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