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I was using tramadol as an agent to ease off of Norco's after long-time use for shoulder issues. I developed a cold and started mixing it with Advil Cold and Sinus (which contains pseudoephedrine). I actually felt very awake, alert and great. I didn't feel any side effects of the cold or withdrawal. I experienced no other side effects, although certain medical sites indicate that the mixture of the two could contribute to ischemic colitis (a usually mild bowel condition marked by abdominal cramps, gas, etc. that usually corrects itself after a couple days). I think you would be okay mixing the two, but I wouldn't do it for long (both are potentially addictive).

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Q: If you take tramadol with pseudoephedrine any side effects?
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