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IgG and IgM can fix complement by activating the C3 protein at the end of the complement cascade allowing ADCC (antibody dependent cell- mediated cytoxicity) to occur.

I have never heard of an IgC antibody.

In humans there are only 5 classes of antibodies: IgM, IgG, IgA. IgD & IgE.

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Q: In addition to IgC the antibodies that can fix complement are?
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Histoplasma complement fixation?

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