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After a first-time install...

Re-boot your computer into 'safe' mode. That stops most programs running - and loads just the minimum drivers to make the computer usable.

Run an update of the anti-virus program -to download the latest virus definitions.

Run a FULL scan with your anti-virus program - which will check almost every part of the hard-drive. Assuming the program has the option - run a 'boot-time' scan - which will analyse parts inaccessible under normal operations.

Once you've run a full scan, and presumably the program has returned no virus detection - re-boot your computer in 'normal' mode - and you're all set

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