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extrinsic pathway of coagulation the mechanism that produces fibrin following tissue injury, beginning with formation of an activated complex between tissue factor and factor VII and leading to activation of factor X, inducing the reactions of the common pathway of coagulation.

intrinsic pathway of coagulation a sequence of reactions leading to fibrin formation, beginning with the contact activation of factor XII, and resulting in the activation of factor X to initiate the common pathway of coagulation.

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Q: In what general way do the intrinsic and extrinsic mechanisms of clotting differ?
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