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pre-hepatic...water insoluble...rise says liver is overwhelmed or not working....MAJORITY NORMALLY....
What else can I help you with?
What is indirect bilirubin?
Indirect bilirubin is a type of bilirubin that is unconjugated, meaning it is not bound to other compounds in the liver. It is produced when red blood cells break down and is then processed by the liver to be converted into direct bilirubin for excretion. High levels of indirect bilirubin in the blood may indicate liver or gallbladder issues.
What the types of serum bilirubin?
Serum bilirubin is primarily categorized into three types: direct (conjugated) bilirubin, indirect (unconjugated) bilirubin, and total bilirubin. Direct bilirubin is water-soluble and occurs after the liver processes bilirubin, while indirect bilirubin is fat-soluble and represents bilirubin that has not yet been conjugated by the liver. Total bilirubin is the sum of both direct and indirect bilirubin levels in the blood, often measured to assess liver function and diagnose various medical conditions.
Why is indirect bilirubin not seen in urine?
indirect bilirubin cannot be measured in the urine. Indirect bilirubin is in the form of unconjugated bilirubin which is insoluble to water and it is non polar in nature, another is that bilirubin is binded to albumin, which result to high molecular weight that's the reason why it cannot pass to the glomeruli for the glomeruli can only pass through molecules having lower molecular weights.
Why direct bilirubin increased in hepatic jaundice?
In hepatic jaundice, direct bilirubin levels increase due to impaired liver function, which affects the liver's ability to conjugate and excrete bilirubin. When liver cells are damaged or inflamed, such as in hepatitis or cirrhosis, they may not effectively process unconjugated bilirubin into its conjugated form. Consequently, both direct (conjugated) and indirect (unconjugated) bilirubin can accumulate in the bloodstream, leading to jaundice. The increase in direct bilirubin specifically indicates that the liver is attempting to process bilirubin but is unable to eliminate it adequately.
Why might choledocolithiasis cause jaundice?
well, you see.. jaundice is caused by the elevation of UNCONJUGATED bilirubin level in our blood.. a high level of unconjugated bilirubin in blood will enter our body tissue and make our skin looks yellow.bilirubin is metabolized in the liver, thus making the unconjugated bilirubin changed into conjugated one. and these conjugated bilirubin will be excreted to our intestine and it will give color to our urine an feces.in patients with choledocolithiasis, there is an obstruction caused by the gallstone inside the duct where conjugated bilirubin should be excreted.. this obstruction makes the liver unable to metabolize the unconjugated bilirubin, and so the level of unconjugated bilirubin will rise, having effect of jaundice.
What it total bilirubin?
Total bilirubin is a measure of the bilirubin levels in the blood, which is a yellow compound produced during the breakdown of red blood cells. It consists of two fractions: unconjugated (indirect) bilirubin, which is not water-soluble and is processed by the liver, and conjugated (direct) bilirubin, which is water-soluble and excreted in bile. Elevated levels of total bilirubin can indicate liver dysfunction, bile duct obstruction, or hemolysis. Testing total bilirubin is often part of a liver function panel to assess liver health.
What is the difference between conjugated and unconjugated bilirubin?
Conjugated bilirubin is water-soluble and has undergone processing in the liver to become more easily excreted in bile. Unconjugated bilirubin is insoluble in water and is the form that results from the breakdown of hemoglobin in red blood cells. They differ in terms of solubility and the liver's processing involvement.
Can indirect bilirubin be more than total bilirubin?
yes
How do you read SBilirubin test results for typhoid fever?
In typhoid fever, elevated serum bilirubin levels can indicate liver involvement or hemolysis. The total bilirubin test measures both direct (conjugated) and indirect (unconjugated) bilirubin; in typhoid, you may often see an increase in indirect bilirubin due to hemolysis. It's essential to interpret bilirubin results alongside other clinical findings and tests, such as liver function tests and complete blood count, to assess the severity of the infection and any potential liver complications. Always consult with a healthcare professional for accurate diagnosis and treatment options.
What does total serum bilirubin produce?
Total serum bilirubin measures the levels of bilirubin in the blood, which is a byproduct of the breakdown of red blood cells. Elevated levels can indicate liver dysfunction, bile duct obstruction, or hemolytic anemia. Clinically, it helps diagnose conditions such as jaundice and liver disease. Total bilirubin is typically divided into direct (conjugated) and indirect (unconjugated) fractions to provide further insight into the underlying cause of elevation.
What is the normal percent of bilirubin?
The normal total bilirubin level in adults typically ranges from 0.1 to 1.2 milligrams per deciliter (mg/dL). This includes both direct (conjugated) and indirect (unconjugated) bilirubin. Values can vary slightly based on the laboratory and individual factors, so it's essential to consult a healthcare provider for specific interpretations. Elevated bilirubin levels may indicate liver dysfunction, hemolysis, or other medical conditions.
What effect on the bilirubin molecule does ultraviolet light have?
Ultraviolet light helps convert unconjugated bilirubin into its water-soluble form, called photoisomerized bilirubin. This process, known as phototherapy, helps the liver excrete bilirubin more easily, reducing the risk of jaundice in newborns.
